Dr. Angela Mabb, Principal Investigator
Angela "Angie" Mabb earned her Ph.D. at the University of Wisconsin-Madison in 2007 in Molecular and Cellular Pharmacology. She then became a Postdoctoral Fellow in the Neurobiology Department at Duke University in the laboratory of Dr. Michael D. Ehlers. From there, she continued her postdoctoral training in the Department of Cell Biology and Physiology at the University of North Carolina-Chapel Hill in the laboratories of Dr. Ben Philpot and Dr. Mark Zylka. Angela's background is strongly rooted in Molecular Biology. The goal of her lab is to marry modern molecular biology techniques with Neuroscience. The main focus of her lab is to study how ubiquitin-dependent pathways mediate cognition and how deficiencies in these pathways cause neurological disease.
Wei Wei, Postdoctoral Fellow
Wei Wei received her Ph.D. degree in Immunology from South Medical University, China in 2013 where her project was focused on dysfunctional presynaptic regulation of striatal medium spiny neurons in mouse models of Parkinson’s disease. She then became a Postdoctoral Fellow in the department of Physiology at the University of Tennessee working on neural mechanisms driving food intake in the obese. She was particularly focused on how diet and body weight affect excitability of neuron populations responsible for food intake. With Dr. Mabb, she integrates electrophysiology, optogenetic, and molecular biology techniques to understand pathways associated with neurological dysfunction.
Dominique Granville, Neuroscience Master's Student
Zachary (Zack) Allen, Research Technician
After almost ten years as a commercial fisherman and boat captain in Virginia Beach, VA., Zack jumped ship to pursue his bachelor’s degree at Georgia State. As a recent graduate of GSU’s Neuroscience Institute, Zack remains passionate about research. While his passion is mostly related to cognitive and behavioral modalities, all fields of neuroscience are of interest to him. Zack is currently taking time to expand his experience and knowledge in the laboratory setting before continuing on to graduate school to pursue his Ph.D. While not in the lab, Zack likes to chase big waves as an avid surfer. Link
Nitheyaa Shree Ramesh, Neuroscience Undergraduate
Nitheyaa is currently pursuing her B.S. in Neuroscience at Georgia State University, as a Presidential Scholar in the Honors College. Before joining the Mabb Lab, she was an undergraduate research assistant in the Pallas Lab, where she studied the effect of visual experience on the morphology of horizontal cells in the sSC. She was awarded the Goldwater Scholarship for her work in the Pallas Lab. She is currently the Vice President of the Undergraduate STEM Research Society and has helped start an Undergraduate Research Seminar Series at GSU. Apart from her passion for science, she is an aspiring musician who plays six instruments and performs professionally around the world with her sister. Link
Mohammad (Amin) Ghane, Neuroscience Institute Graduate Student
Amin graduated from the University of Illinois at Urbana-Champaign in 2015 with a B.S. in Molecular and Cellular Biology. He began his research in neuroscience as a member of the laboratory of Dr. Joshua Gulley, where his undergraduate thesis used biochemical and behavioral techniques to elucidate the mechanisms by which a bioactive metabolite contributed to the amelioration of age-related deficits in learning and memory. Following graduation, Amin spent two years as a research technician for Dr. Catherine Christian. There, he used techniques such as in vivo optogenetics, chemogenetics, and EEG to study astrocytic modulation of seizure susceptibility; explored mechanisms of neuroendocrine dysfunction in a model of temporal lobe epilepsy; and helped to characterize altered behavior and neurotransmission in a mouse strain lacking a key neuropeptide. With Dr. Mabb, he intends to use cutting-edge in vivo neuroimaging techniques to study the role of ubiquitin-mediated immediate early gene turnover in learning and memory related tasks. Link
Dina Yakout, Neuroscience Institute Graduate Student
Dina received her degree in Medicine from Alexandria University, Egypt in 2014. After graduation, she moved to the United States and joined Emory University’s Neurology Department to work on Alzheimer’s disease clinical trials. Pursuing her interest in neurodegenerative disease research, she next joined Dr. Morten Raastad’s lab at Emory University’s School of Medicine to investigate the morphological changes that occur in Alzheimer’s disease in unmyelinated grey matter axons. With Dr. Mabb, she is studying the role of protein ubiquitination in synaptic plasticity and is interested in how this pathway contributes to neurodegenerative disorders like Alzheimer’s disease. Link
Dustin Grossman, Neuroscience Postbaccalaureate
Dustin received his B.S. in Neuroscience in 2020. He was a member of the honors college and the neuroscience honors program, Nu Rho Psi. His research is focused on understanding the role of RNF216 as a regulator in neuroinflammatory pathways. Dustin was the treasurer for Pads for Princesses, a student organization dedicated to helping those experiencing homelessness and spent the last three years volunteering at Children's Healthcare of Atlanta. He is also a licensed Advanced Emergency Medical Technician and hopes to earn his MD. In his spare time, Dustin enjoys music and can play seven instruments.
Arlene George, Neuroscience Institute Graduate Student
Arlene received her B.S. in Cellular and Molecular Neuroscience with a minor in Psychology at Temple University in 2013. As an undergraduate, she conducted research with Dr. Prasun Datta where she investigated the mechanism of how the manipulation of the glutamate transporter, EAAT2, causes excitotoxicity in astrocytes. Upon graduation, Arlene worked as a research technician at the University of Georgia in Dr. Rick Tarleton's lab. There she investigated the role of Trypanosoma cruzi in Chagas disease where she determined the efficacy of novel trypanocidal compounds and implemented the CRISPR-Cas9 system to identify targets of drug action into trypanosomal organisms. Currently, Arlene is developing mouse models to understand the role of RNF216 in Gordon Holmes cerebellar ataxia. Link
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